However, the skeletal effects of vitamin D deficiency in adults and older adults (aged >65 years), and the potential extra-skeletal effects of vitamin D are more controversial. There is consensus that daily intake of 400 IU of vitamin D can prevent nutritional rickets in infants and children 1. This conclusion does not contradict older guidelines that severe vitamin D deficiency should be prevented or corrected. In conclusion, supplementation of vitamin D-replete individuals does not provide demonstrable health benefits. Four Mendelian randomization studies found an increased risk of multiple sclerosis in individuals with genetically lowered serum 25OHD concentrations. Over 60 Mendelian randomization studies, designed to minimize bias from confounding, have evaluated the consequences of lifelong genetically lowered serum 25OHD concentrations on various outcomes and most studies have found null effects. Post hoc analysis has suggested some extra-skeletal benefits for individuals with vitamin D deficiency. The VITAL, ViDA and D2d randomized clinical trials (combined number of participants >30,000) indicated that vitamin D supplementation of vitamin D-replete adults (baseline serum 25OHD >50 nmol/l) does not prevent cancer, cardiovascular events, falls or progression to type 2 diabetes mellitus.

However, the causal link between vitamin D and many extra-skeletal outcomes remains unclear. There is consensus that severe vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) concentration 50 nmol/l for optimal bone health in older adults. Preclinical and observational data suggest that the vitamin D endocrine system has a wide spectrum of skeletal and extra-skeletal activities.

Your doctor might also prescribe intravenous fluids and medications, such as corticosteroids or bisphosphonates.Vitamin D supplementation can prevent and cure nutritional rickets in infants and children. Treatment includes stopping vitamin D intake and restricting dietary calcium. An increased intake of vitamin D supplements by the general population and a growing number of prescriptions of therapeutic doses (including very high doses) without medical monitoring might result in a greater risk of exogenous hypervitaminosis D, with symptoms of hypercalcemia also known as vitamin D toxicity. Kidney complications: This is because having too much vitamin D in the body can lead to high levels of calcium, which can lead to water loss through too much urination and calcification of the kidneysHypercalcemia can also cause the blood vessels of the kidneys to constrict, which leads to decreased kidney functionīecause of the growing awareness of vitamin D deficiency and related health problems, vitamin D became a popular supplement, and its use has increased markedly.It further impacts mental health as well.

Altered mental health: Depression, mood swings, psychosis or feeling confused is another set of symptoms that are caused by hypercalcemia.

It can cause digestive distress, nausea, constipation, stomach pain etc.

Gastrointestinal symptoms: Due to dangerously high levels of vitamin D, there will be an increase in calcium levels too.

This may lead to the development of hypercalcemia that affects the rate of calcium absorption and causes further distress in the body.

Elevated calcium levels: Vitamin D is important for the body as it also helps to absorb calcium from the diet we take.

Elevated Blood Level: High levels of vitamin D supplement intake can cause an increased level of blood vitamin D that impacts internal organ functioning.

Vitamin d supplement side effects